Tyrosine (500 gram)

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Oversikt

Tyrosine (500 gram)
Tyrosin stabiliserer humøret og øker motstandskraften under stress med en aminosyre som raskt krysser blod-hjerne-barrieren. Detbidrar til å danne mer av signalstoffene dopamin, adrenalin og noradrenalin. Dopamin omtales gjerne som et” velværesignalstoff” som er ansvarlig for den gode følelsen vi får fra sex, en god klem og god musikk. Adrenalin og noradrenalin fungerer i hjernen og kroppen både som signalstoffer og hormoner.

De har uvurderlig betydning i dine reaksjoner på fysisk og psykisk stress. Tyrosin kan gi en positive «domino»-effekt på kroppens hormonsystem som kan bidra til å normalisere nivået ikke bare dopamin, men også GABA, testosteron og stoffskiftehormon.

Dette kan bidra til en rekke positive effekter ved bl.a. økt energinivå, økt velvære, økt libido mm.
Bruk og dosering: Vanlig lavdosetilskudd er normalt fra 500 mg til 2000 mg pr. dag, som også har målbare positive effekter på velvære og energi. Det er i ulike studier brukt 150 mg pr. kilo kroppsvekt. Veier man 80 kg betyr det et terapeutisk inntak på 12 gram pr. dag. Tyrosin virker gjerne litt oppkvikkende, så begynn gjerne med 1000 mg om morgenen og 1000 mg før middag. Enkelte kan bli litt urolig i maven av store doser. Bruker man medisiner som påvirker dopamin-produksjonen, er det fornuftig å ta disse med 2-3 timers avstand fra tyrosin da de kan konkurrere om opptaket i tarmen.

ENGELSK:

Tyrosine is a powerful aromatic amino acid that is a building block for dopamine, epinephrine, norepinephrine, and thyroid hormones. Tyrosine supplements are nootropics and adaptogens that help with performance during times of stress. Many people find that it helps significantly with fatigue from stress.
Tyrosine is a precursor to neurotransmitters, which include dopamine, norepinephrine, and epinephrine. Elevated levels of tyrosine increase the production of these neurotransmitters when our bodies need more of them. However, these situations have to be sufficiently challenging to require the extra release of neurotransmitters and subsequent depletion of these neurotransmitters. To maintain optimal neural performance, tyrosine supplementations prevented the neurotransmitters from depleting 

1) Tyrosine Replenishes Cognitive Resources Used in Memory
Tyrosine supplements restored certain cognitive resources used to increase working memory. Working memory is responsible for the continued updating and maintenance of memory. Studies showed that tyrosine only replenished certain cognitive resources when the resources get used up, so only challenging situations that require the use of these cognitive resources see an enhancement of the cognitive resources

2) L-Tyrosine Is a Building Block of Thyroid Hormones
Thyroid hormones control energy production in the body, aiding in the repair and renewal of damaged cells, while increasing resistance to constant stress. In a bird study, chicks with induced tyrosine deficiencies had much lower levels of T3 and T4, common thyroid hormones, in their blood. Birds that were given only phenylalanine supplements, which is the direct precursor to tyrosine, did not gain as much weight as birds given phenylalanine plus tyrosine supplements. This evidences that tyrosine supplementation helped in the growth of the chicks. In rat studies where certain rats were put under constant stress, the stressed rats suffered from reductions in T3 and T4 thyroid hormones. This is due to a decrease in the enzymes’ thyroid peroxidase and oxidase, which are crucial for thyroid hormone production. Many depressed patients also suffered from hypothyroidism. Supplementation with tyrosine increased levels of the neurotransmitter norepinephrine, which increased thyroid hormone release. The tyrosine-supplemented rats not only gained less weight, but also had better cognitive function (as measured in maze tests and distance traveled)

3) Tyrosine Increases Dopamine Levels in the Brain
Tyrosine supplementation increased dopamine levels in the striatum of the brain when animals are given treatments that increase dopamine demand. Tyrosine administration also increased dopamine levels in the extracellular fluid of the brain. However, this effect was short-lived as excessive tyrosine in the brain also slowed down neuronal firing. This, in turn, brought the dopamine levels back to the original levels before tyrosine administration.

4) Tyrosine Helps with Performance During Stress
Tyrosine is a precursor to norepinephrine. Stress reduces norepinephrine levels in the brain (locus coeruleus, hippocampus, and the hypothalamus). When rats were subjected to shock, norepinephrine levels dropped heavily. But, when tyrosine was injected into the rats, the norepinephrine levels remained constant. This is most likely caused by the fact that tyrosine enhanced the rate of norepinephrine production during stressful situations. The added tyrosine caused the rats to show no behavioral deficits while rats that did not get the tyrosine supplements did show behavioral changes resulting from stress. It was also hypothesized that tyrosine may improve physical performance only if the exercise being done produces enough cognitive stress and depletes dopamine or norepinephrine levels 

5) Tyrosine May Improve Attention Deficit Disorders
Clinical trials of using tyrosine to try to improve attention deficit disorder symptoms in humans showed some positive results. Of the 12 adults that volunteered for the clinical trials, eight of them showed some form of clinical improvement in two weeks.However, after six weeks, all eight of the patients developed a tolerance to the tyrosine and improvements stalled. Further investigation into how tyrosine may be used to cure attention deficit disorders needs to be done. Impaired neurotransmitter energy production may be a predisposition for attention deficit disorder. Although this only accounts for 5 to 10% of the attention deficit disorder cases, it is more likely that such cases would benefit more from tyrosine supplementation 

6) Tyrosine to Treat Depression
Tyrosine was found to help depression in certain patients in some clinical trials. A single case, placebo-controlled, case involving a 30-year old woman suffering from depression showed marked improvement after tyrosine therapy. Placebo treatments immediately showcased a return of depression symptoms. Continued tyrosine therapy brought back a marked improvement. Further trials regarding two other patients with depression also showed improvement regarding symptoms . However, larger clinical trial of 65 patients did not support that tyrosine can be used as an antidepressant. Possibly, this was because depression is dependent on many factors, not simply a lack of dopamine or norepinephrine. Tyrosine might only help depression patients with low dopamine and norepinephrine levels

7) Tyrosine for Treatment of Parkinson’s Disease
Nine patients who had Parkinson’s disease were treated with tyrosine and probenecid. These patients showed an increase in homovanillic acid in the cerebrospinal fluid. The presence of homovanillic acid, a product of dopamine energy production, correlates to the fact that dopamine is being released in the brain. Because Parkinson’s is strongly linked to the degeneration of neurons that release dopamine, increased levels of homovanillic acid could be good proof that tyrosine may be used to treat the disease 

8) Tyrosine Improves Inhibition
Tyrosine administration could help reduce unwanted tendencies .One study describes these tendencies as inhibitory control. When patients were asked to perform a stop-signal task (where the patient clicks stop when a green arrow turns red), patients with tyrosine injections performed better than those with a placebo 

9) Tyrosine Improves Mood During Winter Blues
During stressful situations such as the cold or elevated altitudes, increased tyrosine levels improved mood by lowering the intensities of symptoms from the cold and lowered oxygen levels. In a long-term study, patients in Antarctica were given tyrosine supplements daily over the summer and winter. However, during only stressful conditions in the winter months did the tyrosine supplements help to improve mood (by 47%). Summer conditions were not harsh enough to illicit a response.

 

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