SUPER BOOSTER WITH MACUGUARD OCULAR SUPPORT

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SUPER BOOSTER WITH MACUGUARD OCULAR SUPPORT, 60 SOFTGELS

Super Booster with MacuGuard® Ocular Support
60 softgels
Item Catalog Number: 01980
Most people don’t get enough oil-based nutrients from their diet. Super Booster solves that problem with a once-a-day softgel that provides high potencies of fat-soluble nutrients and other compounds.

Just one Super Booster provides:

 

Vitamin K2: Studies show vitamin K2 provides superior benefits for bones, arteries, and other tissues. The MK-4 form of vitamin K2 is the most rapidly absorbed, but only remains active in the blood for a few hours. The MK-7 form of K2, however, remains bioavailable for a sustained 24 hours. Super Booster provides a potent dose of MK-7 and MK-4 (along with vitamin K1) to keep calcium in the bones and out of the arteries.
Gamma tocopherol: Taking only alpha tocopherol displaces the critically important gamma tocopherol from cells in the body. Gamma tocopherolalso quenches a dangerous free radical (peroxynitrite) that plays a major role in age-related decline. It is vital that those taking vitamin E supplements also consume at least 200 mg a day of gamma tocopherol.
MacuGuard® Carotenoid Phospholipid Blend: To support eye health, macular density and healthy vision, MacuGuard® provides zeaxanthin, meso-zeaxanthin, and lutein. Now that these carotenoids are included in the Super Booster formula, most people do not need to take a separate MacuGuard® supplement.
Black currant extract: Cyanidin-3-glucoside is the anthocyanin-rich purple pigment found in European black currant extract that helps promote eye comfort and health.
Sesame lignans: Help boost tissue levels of gamma tocopherol via several different mechanisms.
Lycopene: Evidence suggests those who ingest this carotenoid enjoy healthier prostate function. Lycopene also helps guard against LDL oxidation.
Chlorophyllin: Scientific studies indicate chlorophyllin may protect against environmentally induced DNA damag

 

 

Detaljer

Supplement Facts

Serving Size 1 softgel

Servings Per Container 60

Amount Per Serving

Vitamin C (as ascorbic acid)

95 mg

Vitamin E (as D-alpha tocopherol)

45 IU

Vitamin K activity

2200 mcg

From:

 

Vitamin K1 (as phytonadione)

1000 mcg

Vitamin K2 (as menaquinone-4)

1000 mcg

Vitamin K2 (as menaquinone-7)

200 mcg

Vitamin B12 (as cyanocobalamin)

300 mcg

Chlorophyllin (from sodium magnesium chlorophyllin)

100 mg

Gamma E Mixed Tocopherols

359 mg

MacuGuardTM Carotenoid Phospholipid Blend 
Phospholipids, marigold extract (flower) [providing 10 mg free lutein, 4 mg meso-zeaxanthin &trans-zeaxanthin)

145 mg

C3G (Cyanidin-3-glucoside) [from European black currant extract (fruit)]

2.2 mg

Lycopene proprietary blend [from Micronized Lycopene and Tomat-O-Red® natural tomato extract (fruit)]

10 mg

Sesame seed lignan extract

20 mg

Other ingredients: gelatin, flax seed oil, soy lecithin (phosphatidylcholine), glycerin, corn oil, safflower oil, olive oil, purified water, sunflower oil, sunflower lecithin, soy fatty acids, silica, annatto, potato maltodextrin.

Contains soybeans.

Tomat-O-Red® is a registered trademark of LycoRed, LTD. LuteinPlus® and Mz® are registered trademarks of NutriProducts Ltd., UK, licensed under U.S. Patent 8,623,428.

Dosage and Use
  • Take one (1) softgel daily with food, or as recommended by a healthcare practitioner.
Caution

If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.

Warnings
  • KEEP OUT OF REACH OF CHILDREN
  • DO NOT EXCEED RECOMMENDED DOSE
  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

 

New Studies Validate Powerful Protection Against Age-Related Vision Loss

 

By Michael Downey

New Studies Validate Powerful Protection Against Age-Related Vision Loss  

If you’re able to read this, you should consider yourself lucky. Millions of older Americans are suffering from age-related vision loss and struggle with everyday activities like reading or driving.

It is estimated that a startling 20.5 million Americans have cataracts, while 1.8 million suffer age-related macular degeneration.1,2 These numbers are expected to double in the next few decades.3,4

Recent research has revealed that these ocular diseases share common underlying causes, including oxidative stress, inflammation, and premature apoptosis (cell death).5

Fortunately, a class of nutrients has been found to target all these underlying causes of vision loss.

Xanthophylls —including luteinzeaxanthin, and meso-zeaxanthin—were long ago shown to provide powerful protection against devastating age-related vision loss.5-7

What will impress long-term Life Extension® members are new studies published in 2014 showing that these xanthophyllsconfer meaningful protection against the most common forms of degenerative eye disease.

Xanthophylls Help Prevent Macular Degeneration

Xanthophylls Help Prevent Macular Degeneration  

Xanthophylls, the subclass of carotenoids responsible for giving the macula its yellow color, have been found to provide powerful protection against age-related macular degeneration.8

Macular degeneration is the leading cause of blindness in aging adults.9-11 It results from progressive loss of light-sensing nerve cells in the macula, or central part of the retina. This is the area where these cells are most densely packed, which is why the macula provides us with the greatest level of visual acuity (the ability to distinguish fine details).12-14 As macular degeneration progresses, central vision is lost, gradually diminishing one’s ability to engage in the many daily activities that require sharp vision.15

Research suggests that zeaxanthin and other xanthophylls may help prevent macular degeneration by increasing thestructural density of the eye’s macular pigment.

Swiss scientists found that supplementing with just 10 to 20 daily mg of either lutein, zeaxanthin, or a combination of the two could increase the average plasma concentration of these xanthophylls by up to 27-fold. The researchers found that lutein wound up primarily in the most central region of the retina, while zeaxanthin was deposited over a wider area, suggesting that both nutrients are needed for maximum retinal health.16

Indeed, numerous studies have shown that higher dietary intakes of this powerful duo correspond with lower rates of macular degeneration and cataracts.17,18 In one study, epidemiologists found a 43% decrease in macular degeneration risk among people with the highest dietary carotenoid intakes—particularly zeaxanthin and lutein—compared with those with the lowest intakes.19

A remarkable double-blind, placebo-controlled study from 2014 demonstrated significant vision improvement with daily oral supplementation of 10 mg of lutein plus 2 mg of zeaxanthin—including a significant increase in macular pigment optical density.20

Also in 2014, a study in the journal Retina demonstrated the importance of supplementing with meso-zeaxanthin in addition to lutein and zeaxanthin. The researchers found that groups taking meso-zeaxanthin along with lutein and zeaxanthin significantly increased the optical density of macular pigment when compared to groups taking lutein and zeaxanthin without meso-zeaxanthin.21

Although there is no daily minimum for these xanthophylls, research suggests that a total daily intake of 6 mg of lutein and zeaxanthin is associated with a reduced risk of age-related macular degeneration.22

WHAT YOU NEED TO KNOW
Xanthophylls Offer Potent Eye Protection

Xanthophylls Offer Potent Eye Protection

  • An estimated 20.5 million Americans have cataracts, and another 1.8 million suffer age-related macular degeneration. Both numbers are expected to double in the next few decades.
  • New 2014 studies validate what Life Extension members have long known: Xanthophylls, such as lutein, zeaxanthin, and meso-zeaxanthin, have once again been shown to provide powerful protection against devastating age-related vision loss, including macular degeneration and cataracts.
  • A novel flavonoid called cyanidin-3-glucoside (C3G) has been shown to combat age-related night blindness, further supporting xanthophyll activity.

Improvements For Macular Degeneration Sufferers

In addition to preventing the onset of macular degeneration, xanthophylls have been found to improve vision in those who are already suffering from this vision-robbing disease.

Italian ophthalmologists randomized 27 patients with early age-related macular degeneration and discovered that the patients taking a dietary supplement that included lutein and zeaxanthin showed highly significant increases in electrical activity in the central areas of their retinas—where maximum visual acuity is generated—while the control patients showed no significant changes.23

In another rigorous trial, 90 patients with macular degeneration received either 10 mg of lutein daily, 10 mg of lutein along with a vitamin-mineral mix, or a placebo. After 12 months of treatment, visual acuity increased for both the lutein-only and the lutein-plus-vitamin-mineral groups. The lutein-only patients also reported a subjective improvement in their vision on a standard scale, while placebo recipients had no significant change in any of the measured outcomes.24

ENSURING ADEQUATE XANTHOPHYLL INTAKE
Three Nutrients Critical to Macular Structure

Life Extension members were long ago educated about the critical importance of supplementing with luteinzeaxanthin, and meso-zeaxanthin.

A large number of our members supplement with these xanthophylls to protect their vision, yet omit nutrients likevitamin K and gamma tocopherol that protect other areas of the body.

To ensure members are getting all these fat-soluble nutrients, Life Extension members can now obtain a combination of lutein,zeaxanthinmeso-zeaxanthinvitamins K1 and K2gamma tocopherol, and other nutrients all in one upgraded formula.

Xanthophylls: Nature’s Natural Eye Protection

The carotenoids known as xanthophylls provide broad support for eye cells against age-related insults such as oxidative stress and inflammation.

Compared to most other organs, the eye is particularly susceptible to oxidative damage due to its exposure to light and its high metabolism.40

Each of the xanthophylls has been shown to target these shared pathologic pathways, resulting in potent protection against common, age-related causes of vision loss.

Lutein And Zeaxanthin

Of the 20 to 30 carotenoids found in human blood and tissues, the two most prominent found in your lens and retina arelutein and zeaxanthin.22 Both of these xanthophylls, referred to as the macular pigment, are concentrated in the macula, the specialized central area of the retina that is responsible for detailed vision due to its high concentration of light-detecting cone cells. Lutein and zeaxanthin are believed to limit damage to the retina by absorbing incoming, high-energy blue light and by quenching reactive oxygen species.22,25

Meso-Zeaxanthin

In addition to lutein and zeaxanthin, meso-zeaxanthin offers much-needed, broad-spectrum, structural support for the aging macula. While lutein and zeaxanthin are found in egg yolks and colorful fruits and vegetables,41 meso-zeaxanthin is only found in a few food sources. This xanthophyll may be converted in the retina from ingested lutein.42 With age, it has been theorized that the ability to convert lutein into meso-zeaxanthin may decline.43 If taken as a supplement, meso-zeaxanthin is absorbed into the bloodstream and raises macular pigment density.42

Prevention And Improvement Of Cataracts

Studies have confirmed similar effects in cataracts, another main cause of adult blindness.25,26 A cataract is a clouding of the lens, which causes light to bend and scatter in ways that prevent the formation of a sharp image on the retina.27-29

Studies have found that higher intakes of lutein and zeaxanthin are associated with reduced risk of cataracts. For example, the Nurses’ Health Study examined the impact of 12 years of carotenoid consumption on cataract formation in more than 77,000 female nurses over the age of 45. Women with the highest intake of zeaxanthin and lutein had a 22% lower risk of cataract extraction (cataracts severe enough to require surgical removal).30

A randomized, placebo-controlled study examined the effects of lutein and vitamin E on visual function in 17 adults who had already been clinically diagnosed with age-related cataracts. The patients supplemented with 15 mg of lutein, 100 mg of vitamin E, or a placebo three times weekly for up to two years. Those in the lutein arm of the study demonstratedimprovements in visual performance, including visual acuity and glare sensitivity. By contrast, visual acuity was merely maintained in the vitamin E group and worsened in the placebo group.31

In a later study, Australian researchers conducted a five-year investigation of 2,322 people 40 years old and older. They found an astonishing 40% lower energy-adjusted rate of cataracts occurring at the center of the lens for every 1 mg increase in subjects’ daily intake of lutein and zeaxanthin.32

Night Blindness

Night blindness—impairment of our ability to see in the dark—occurs with age, even in the absence of ocular disease. It is caused because rhodopsin, a compound in the eyes that absorbs light in the retina, regenerates more slowly as we age.33

Fortunately, a novel flavonoid called cyanidin-3-glucoside (C3G) can combat night blindness by stimulating the regeneration of rhodopsin.34-36 Although it does not belong to the xanthophyll group of compounds, it is important to aging people who suffer night vision loss.

C3G is a purple pigment in the anthocyanin family of flavonoids that is found in high concentrations in dark fruits such as blackberries and black currants. C3G has been shown to protect retinal cells against the harmful oxygen free radicals that are triggered by light.37,38 C3G and other cyanidin components of berries have also been shown to exert neuroprotective effects on retinal cells.39

Summary

Age-related macular degeneration and cataracts—both associated with aging—are primary causes of the loss of vision that afflict millions of Americans.

These distinctly different diseases all share mechanistic pathways, including oxidative stress, inflammation, and apoptotic (cell death) factors. These common pathways are blocked by novel carotenoids known as macular xanthophylls, which specifically accumulate in the eye and structurally support the aging macula and retina.

Xanthophylls —including lutein, zeaxanthin, and meso-zeaxanthin—powerfully inhibit vision-robbing diseases. Supporting this activity, the anthocyanin C3G can protect retinal cells by stimulating rhodopsin regeneration and combating night blindness.

If you have any questions on the scientific content of this article, please call a Life Extension® Health Advisor at1-866-864-3027.

References

  1. Eichenbaum JW. Geriatric vision loss due to cataracts, macular degeneration, and glaucoma. Mt Sinai J Med. 2012 Mar-Apr;79(2):276-94.
  2. Available at: http://www.cdc.gov/visionhealth/basic_information/eye_disorders.htm. Accessed September 26, 2014.
  3. McCarty CA. Cataract in the 21st Century: lessons from previous epidemiological research. Clin Exp Optom. 2002 Mar;85(2):91-6.
  4. National Eye Institute. Archives of Ophthalmology. 122(4):444-676.
  5. Huynh TP, Mann SN, Mandal NA. Botanical compounds: effects on major eye diseases. Evid Based Complement Alternat Med. 2013;2013:549174.
  6. Widomska J, Subczynski WK. Why has nature chosen lutein and zeaxanthin to protect the retina? J Clin Exp Ophthalmol. 2014 Feb 21;5(1):326.
  7. Piermarocchi S, Saviano S, Parisi V, et al. Carotenoids in age-related maculopathy Italian study (CARMIS): two-year results of a randomized study. Eur J Ophthalmol. 2012 Mar-Apr;22(2):216-25.
  8. Whitehead AJ, Mares JA, Danis RP. Macular pigment: A review of current knowledge. Arch Ophthalmol. 2006;124:1038-45.
  9. Nita M, Strzałka-Mrozik B, Grzybowski A, Mazurek U, Romaniuk W. Age-related macular degeneration and changes in the extracellular matrix. Med Sci Monit. 2014 Jun 18;20:1003-16.
  10. Haddad S, Chen CA, Santangelo SL, Seddon JM. The genetics of age-related macular degeneration: a review of progress to date. Surv Ophthalmol. 2006 Jul-Aug;51(4):316-63.
  11. Birch DG, Liang FQ. Age-related macular degeneration: a target for nanotechnology derived medicines. Int J Nanomedicine. 2007;2(1):65-77.
  12. Weber A, Elsner AE, Miura M, Kompa S, Cheney MC. Relationship between foveal birefringence and visual acuity in neovascular age-related macular degeneration. Eye (Lond). 2007 Mar;21(3):353-61.
  13. Bok D. Evidence for an inflammatory process in age-related macular degeneration gains new support. Proc Natl Acad Sci USA. 2005 May 17;102(20):7053-4.
  14. Available at: http://www.nei.nih.gov/health/maculardegen/armd_facts.asp. Accessed September 22, 2014.
  15. Whitmore SS, Mullins RF. Transcriptome changes in age-related macular degeneration. BMC Med. 2012 Feb 27;10:21.
  16. Schalch W, Cohn W, Barker FM, et al. Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin—the LUXEA (LUtein Xanthophyll Eye Accumulation) study. Arch Biochem Biophys. 2007 Feb 15;458(2):128-35.
  17. Ribaya-Mercado JD, Blumberg JB. Lutein and zeaxanthin and their potential roles in disease prevention. J Am Coll Nutr. 2004 Dec;23(6 Suppl):567S-87S.
  18. Moeller SM, Voland R, Tinker L, et al. Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the carotenoids in the age-related eye disease study (CAREDS), an ancillary study of the Women’s Health Initiative. Arch Ophthalmol. 2008 Mar;126(3):354-64.
  19. Seddon JM, Ajani UA, Sperduto RD, et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group. JAMA. 1994 Nov 9;272(18):1413-20.
  20. Available at: http://newhope360.com/regulatory/dsm-kemin-affirm-science-supporting-eye-health?NL=NH-07&Issue=NH-07_20140716_NH-07_132&sfvc4enews=42&cl=article_6 . Accessed September 22, 2014.
  21. Sabour-Pickett S, Beatty S, Connolly E, et al. Supplementation with three different macular carotenoid formulations in patients with early age-related macular degeneration. Retina. 2014 Sep;34(9):1757-66.
  22. Rasmussen HM, Johnson EJ. Nutrients for the aging eye. Clin Interv Aging. 2013;8:741-8.
  23. Parisi V, Tedeschi M, Gallinaro G, et al. Carotenoids and antioxidants in age-related maculopathy Italian study: multifocal electroretinogram modifications after one year. Ophthalmology. 2008 Feb;115(2):324-33.
  24. Richer S, Stiles W, Statkute L, et al. Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry. 2004 Apr;75(4):216-30.
  25. Moeller SM, Jacques PF, Blumberg JB. The potential role of dietary xanthophylls in cataract and age-related macular degeneration. J Am Coll Nutr. 2000 Oct;19(5 Suppl):522S-7S.
  26. Vu HT, Robman L, Hodge A, McCarty CA, Taylor HR. Lutein and zeaxanthin and the risk of cataract: the Melbourne visual impairment project. Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3783-6.
  27. Available at: http://www.nei.nih.gov/health/cataract/cataract_facts.asp. Accessed September 24, 2014.
  28. Takata T, Oxford JT, Brandon TR, Lampi KJ. Deamidation alters the structure and decreases the stability of human lens betaA3-crystallin. Biochemistry. 2007 Jul 31;46(30):8861-71.
  29. Parkosadze K, Kalmakhelidze T, Tolmacheva M, et al. Persistent biases in subjective image focus following cataract surgery. Vision Res. 2013 Aug 30;89:10-7.
  30. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr. 1999 Oct;70(4):509-16.
  31. Olmedilla B, Granado F, Blanco I, Vaquero M. Lutein, but not alpha-tocopherol, supplementation improves visual function in patients with age-related cataracts: a 2-y double-blind, placebo-controlled pilot study. Nutrition. 2003 Jan;19(1):21-4.
  32. Vu HT, Robman L, Hodge A, McCarty CA, Taylor HR. Lutein and zeaxanthin and the risk of cataract: the Melbourne visual impairment project. Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3783-6.
  33. Jackson GR, Owsley C, McGwin G Jr. Aging and dark adaptation. Vision Res. 1999 Nov;39(23):3975-82.
  34. Matsumoto H, Nakamura Y, Tachibanaki S, Kawamura S, Hirayama M. Stimulatory effect of cyanidin 3-glycosides on the regeneration of rhodopsin. J Agric Food Chem. 2003 Jun 4;51(12):3560-3.
  35. Tirupula KC, Balem F, Yanamala N, Klein-Seetharaman J. pH-dependent interaction of rhodopsin with cyanidin-3-glucoside. 2. Functional aspects. Photochem Photobiol. 2009 Mar-Apr;85(2):463-70.
  36. Yanamala N, Tirupula KC, Balem F, Klein-Seetharaman J. pH-dependent interaction of rhodopsin with cyanidin-3-glucoside. Structural aspects. Photochem Photobiol. 2009 Mar-Apr;85(2):454-62.
  37. Wang Y, Zhang D, Liu Y, et al. The protective effects of berry-derived anthocyanins against visible light-induced damage in human retinal pigment epithelial cells. J Sci Food Agric. 2014 Jun 6. doi: 10.1002/jsfa.6765.
  38. Jang YP, Zhou J, Nakanishi K, Sparrow JR. Anthocyanins protect against A2E photooxidation and membrane permeabilization in retinal pigment epithelial cells. Photochem Photobiol. 2005 May-Jun;81(3):529-36.
  39. Matsunaga N, Imai S, Inokuchi Y, et al. Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo. Mol Nutr Food Res. 2009 Jul;53(7):869-77.
  40. Jang H, Ahn HR, Jo H, et al. Chlorogenic acid and coffeeprevent hypoxia-induced retinal degeneration. J Agric Food Chem. 2014;62(1):182-91.
  41. Sommerburg O, Keunen JE, Bird AC, van Kuijk FJ. Fruits and vegetables that are sources for lutein and zeaxanthin: the macular pigment in human eyes. Br J Ophthalmol. 1998 Aug;82(8):907-10.
  42. Bone RA, Landrum JT, Alvarez-Correa C, Etienne V, Ruiz CA. Macular pigment and serum Response to Dietary Supplementation with Meso-zeaxanthin. Annual meeting of ARVO. May 4, 2003; Fort Lauderdale, FL: Abstract 405/B380.
  43. Kirby ML, Beatty S, Loane E, Akkali MC, Connolly EE, Stack J, Nolan JM. A central dip in the macular pigment spatial profile is associated with age and smoking. Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6722-8.

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