Fast-C® with Dihydroquercetin

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Fast-C® with Dihydroquercetin
120 vegetarian tablets

The active vitamin C in Vitamin C WITH DIHYDROQUERCETIN can:

Help protect your body from oxidative stress
Promote collagen formation and normal iron absorption
Stays longer in your body because of the dihydroquercetin component in the formula
Vitamin C and dihydroquercetin found in VITAMIN C WITH DIHYDROQUERCETIN can help protect your body from oxidative stress and promote collagen formation as well as healthy iron absorption and stays active in the body longer than regular vitamin C supplements.

 

Vitamin C efficacy can be limited because it is quickly utilized and excreted by the body.1 A novel formula sets a new standard for rapid absorption, enhancing the time that vitamin C is delivered for cellular protection.

In two human trials at a distinguished research center, FAST-C® was compared head-to-head with a leading premium brand of “enhanced absorption” vitamin C.2,3 Their findings validate that FAST-C® has faster absorption—and without greater excretion.

Vitamin C neutralizes free radicals,4-7 supports biosynthesis of certain neurotransmitters,8,9 and promotes production of vital tissue (collagen) that supports arterial walls, skin, and bones.7-9 Vitamin C promotes immunity,7,10 boosts lymphocyte glutathione levels,11 and helps regenerate other antioxidants, including vitamin E.12

But because it leaves the body quickly,1 capturing vitamin C’s optimal benefits has required taking supplements several times daily, hoping they’ll be effective without posing a risk for acid-sensitive stomachs. The scientific community has long sought faster-absorbing vitamin C formulas.

A leading brand of “enhanced” vitamin C has been promoted claiming to increase vitamin C bioavailability. A published study in a top nutritional sciences journal found no difference in absorption speed, blood vitamin C increase, or urinary excretion between that product and ascorbic acid (vitamin C).13

The good news? A next-generation FAST-C® supplement has been proven in double-blind, human trials to have faster absorption—combined with equal or greater body retention. This breakthrough—FAST-C®—is available exclusively to Life Extension® members. It also contains dihydroquercetin to enhance vitamin C’s “recycling” power.

FAST-C® with Dihydroquercetin is the only vitamin C product to incorporate:

A proprietary blend of alkalizing minerals that yields an almost completely acid-neutralized (which is better than “buffered”) vitamin C for sensitive stomachs
Piperine (Bioperine®), a multipatented, black pepper alkaloid that significantly accelerates vitamin C absorption, shortening the time to peak plasma concentration3
Dihydroquercetin, a grape leaf derived flavonoid that donates electrons back to vitamin C molecules that have spent their electrons neutralizing free radicals—regenerating vitamin C to work again14
In recognition of this breakthrough, FAST-C® received the prestigious Scientific Achievement Award from Nutrition Business Journal.15

In a soon to be journal-published article, scientists evaluated the FAST-C® formulation in humans. They found that in just 60 minutes the FAST-C® composition generated a “significantly higher” vitamin C blood increase than the leading, enhanced-absorption vitamin C product.2 To further validate these findings, a second clinical trial was conducted to compare two different variations of the formula in FAST-C® with the leading, “enhanced” brand.

One of the FAST-C® formulations produced higher blood concentrations of vitamin C after 30, 60, and even 90 minutes. Despite faster and greater rises in blood vitamin C with FAST-C® the amounts of vitamin C excreted in the urine were no greater than the amount excreted in the urine with the leading “enhanced” brand—which suggests similar or better vitamin C retention by the body.3

References
1. PLoS Med. 2005 Sep;2(9):e307.
2. FASEB J. April 2008;22 Meeting Abstract Supp:689.
3. American College of Nutrition. Annual Meeting, October, 2009.
4. Ann N Y Acad Sci. 1992 Sep 30;669:7-20.
5. Am J Clin Nutr. 1996 Jun;63(6):985S-90S.
6. FASEB J. 1995 Apr;9(7):526-33.
7. Altern Med Rev. 2003 Nov;8(4):359-77.
8. J Nutr. 2007;137:2171-84.
9. Am J Clin Nutr. 1999;69:1086-107.
10. Curr Drug Targets. 2012 Dec 1;13(14):1757-71.
11. Am J Clin Nutr. 2003 Jan;77(1):189-95.
12. Lipids. 2012 Dec;47(12):1193-207.
13. J Amer Dietetic Assoc. 1994;94:779-81.
14. Free Radic Biol Med. 1995 Jul;19(1):45-52.
15. Available at: http://www.scientificfoodsolutions.com/fastC_NBJ_Achievement_Award.html . Accessed January 31, 2013.

 

Detaljer

upplement Facts
Serving Size 1 vegetarian tablet
Servings Per Container 120
Amount Per Serving
Vitamin C (as ascorbic acid)
500 mg
Calcium (as calcium carbonate)
79 mg
Magnesium (as magnesium hydroxide)
8 mg
Bioperine® piperine [from black pepper (Piper nigrum) extract (fruit)]
3 mg
Total Dihydroquercetins [from grape (Vitis vinifera) extract (leaf)]
25 mg
Other ingredients: microcrystalline cellulose, aqueous film coating (purified water, hydroxypropyl methylcellulose, glycerin), stearic acid, croscarmellose sodium, vegetable stearate.
Fast-C® is a registered trademark of Scientific Food Solutions, LLC.
Bioperine® is a registered trademark of Sabinsa Corporation.

Dosage and Use
Take one tablet daily with food, or as recommended by a healthcare practitioner.
Caution
Do not take more than 15 mg per day of Bioperine®.

Vitamin C and Dihydroquercetin

Creating a More Potent Vitamin CBy Mark J. Neveu, PhD
Free radicals (black stream, bottom left to center right) damaging cellular DNA (white, center right). The DNA has originated from the cell nucleus (purple, lower right) and a sectioned cell membrane surrounds it. Vitamin C (blue particles) reduces this damage. LDL particles (orange) are oxidized by free radicals, and protected by vitamin E (yellow hexagons). Oxidized LDL is removed by white blood cells (pink/grey, upper center). These LDL-filled cells form atherosclerotic plaque (brown, upper right).

Every day, our bodies are under continual assault by damaging agents known as free radicals. Generally, both internal and dietary antioxidants do an excellent job of keeping free radicals in check. However, once this balance is disrupted, lethal diseases such as cancer, heart disease, lung disease, diabetes, Parkinson’s disease, arthritis, Alzheimer’s disease, and stroke can be initiated.1-3

A wealth of scientific evidence has repeatedly demonstrated that specialized compounds in fresh fruits and vegetables exert critical protection against free-radical assault.4 Of these, vitamin C and plant substances known as flavonoids may be among nature’s most potent natural antioxidants.1-6

Exciting new studies suggest that a flavonoid called dihydroquercetin, in combination with vitamin C, provides even more powerful, synergistic protection against oxidative stress than either substance alone.

Flavonoids: Nature’s “Biological Response Modifiers”

Scientists have recently begun to attribute many of the beneficial effects of fruits, vegetables, tea, and even red wine to the flavonoid compounds they contain.5,6

Flavonoids perform two important functions in the body. First, they strengthen the body’s immune response to attacks from allergens, viruses, and carcinogens. Second, they act as powerful antioxidants, protecting the body against the oxidative stress and free-radical damage that underlie many cardiovascular, neurological, and diabetic diseases. Studies have shown that those who have increased flavonoid intake clearly demonstrate a decreased incidence and mortality of heart disease.7-10

One of the most important attributes of these flavonoids is their ability to enhance the effects of vitamin C. Vitamin C’s main function in humans is to reduce the dangerous effects of oxidative reactions throughout the body. Unfortunately, because vitamin C is water soluble, it stays in the body for only a very brief time before being excreted. This time frame limits vitamin C’s efficacy.10 Until now, it has been recommended that vitamin C be taken in several doses to maintain optimal benefits. However, flavonoids have been shown to improve the concentration and efficacy of vitamin C throughout the body. This important finding means that you can take less vitamin C while it lasts longer and works harder.11

Dihydroquercetin

One flavonoid, dihydroquercetin, has been found to be extremely beneficial in helping vitamin C re-circulate throughout the body. Additionally, it limits the inactivation or oxidation of vitamin C, which enables vitamin C to last longer in the body.12,13

The addition of this unique flavonoid creates an entirely new way to deliver vitamin C to cells in need of its protection. Now, supplement users can maximize their benefits from longer-lasting and more effective vitamin C.

DIHYDROQUERCETIN FIGHTS CARDIOVASCULAR DISEASE

Dihydroquercetin acts in several ways to help avert cardiovascular disease.

Scientists have demonstrated that dihydroquercetin inhibits lipid peroxidation, a process that often leads to atherosclerosis.14,24,32 In an animal study, dihydroquercetin inhibited the peroxidation of serum and liver lipids following exposure to toxic ionizing radiation.33 Dihydroquercetin’s inhibitory effects on lipid peroxidation are enhanced by both vitamin C and vitamin E.34 By inhibiting the oxidation of harmful low-density lipoprotein (LDL), dihydroquercetin may help prevent atherosclerosis.35

Lowering high levels of low-density lipoprotein (LDL) is one the the major goals of anti-cholesterol or statin therapy as used by mainstream physicians. Studies suggest that dihydroquercetin may be helpful in therapeutic efforts to lower LDL by inhibiting the formation of apolipoprotein B, one of the primary components of LDL.36

Other studies have shown that dihydroquercetin lowers serum and liver lipid and cholesterol concentrations in rats.37A conjugated form of dihydroquercetin known as astilbin inhibits the same enzyme targeted by popular cholesterol-lowering statin drugs such as Lipitor®, Zocor®, and Pravachol®.38

Attacking heart disease from another angle, animal studies showed that dihydroquercetin lowers high blood pressure and normalizes an electrical measure associated with activation of the heart’s pumping chambers (ventricles).39

Synergistic Effects of Vitamin C and Dihydroquercetin

Unlike plants and most animals, humans cannot manufacture vitamin C within the body and therefore must obtain it from external sources. This has led some scientists, including the late Nobel Prize-winning chemist Linus Pauling, to propose that humans would enjoy better health if they supplemented their diets with an amount of the nutrient proportional to the amount produced in animal species that manufacture their own vitamin C. Moreover, aging adults experience a decrease in vitamin C levels, which may contribute to the development of several degenerative diseases, such as cardiovascular disease, cancer, neurodegenerative conditions, and eye disorders.14-16

The combination of vitamin C and dihydroquercetin offers such tremendous promise in preserving and restoring health that it has been approved as a prescription drug in some parts of the world.

VITAMIN C AND DIHYDROQUERCETIN: WHAT YOU NEED TO KNOW
  • A novel bioflavonoid, dihydroquercetin, offers exceptional benefits by enhancing the health-promoting benefits of vitamin C. Dihydroquercetin enhances the effectiveness of vitamin C by extending its period of bioactivity, enhancing its regeneration, and slowing its elimination from the body.
  • Dihydroquercetin offers protection against cardiovascular disease by inhibiting several steps in the disease process. Additionally, dihydroquercetin helps guard nervous system health, prevents the complications of dia-betes, protects the liver against hepatitis-inducing agents, fights infection, and quells inflammation that can lead to dermatitis, arthritis, and pain.
  • Some of vitamin C’s best-known applications are preventing viral infection, enhancing cancer protection, and averting cardiovascular disease and stroke.
  • In some parts of the world, a combination of vitamin C and dihydroquercetin is available as a prescription drug known as Ascovertin. Physicians utilize Ascovertin to manage health conditions that share oxidative stress as an underlying mechanism. Ascovertin has demonstrated efficacy in protecting against stroke, heart attack, and light-induced damage to the eye.
  • Consumers in the United States can use the benefits of a dietary supplement combining dihydroquercetin and vitamin C without a prescription.

In Russia, a drug known as Ascovertin (a complex of dihydroquercetin and vitamin C) is a popular treatment for many health conditions that share oxidative stress as an underlying mechanism. Since oxidative stress characterizes many of the degenerative conditions associated with aging,1-3 Ascovertin’s potential applications are quite broad.

For example, Ascovertin may have applications in the management of stroke, a crippling, often fatal condition marked by a diminished supply of blood and oxygen to the brain. Studies of the effects of oxygen deprivation in rat brains demonstrated that Ascovertin decreased the damage caused by lack of blood flow. Additionally, Ascovertin restored normal structure and electrochemical activity to nerve synapses, the junctions that allow nerve cells to transmit information.17,18

The Russian Academy of Medical Sciences recently conducted two clinical studies of Ascovertin in 52 patients with impaired blood flow to the brain. Ascovertin was administered for 21 days. The resulting decrease in blood viscosity and blood-clotting tendency improved attention, memory, and mental performance, relieved vertigo, normalized sleep, relieved headaches, and decreased fatigue.19,20 No such changes were observed in the age-matched control patients.

COMMON APPLICATIONS OF VITAMIN C

Long considered essential to optimal health, vitamin C may offer targeted protection against viral infections, cancer, cardiovascular disease, and stroke.

  • Viruses. Vitamin C is widely used to support the immune system’s protection against colds and flus. In adults and children, the preventive use of vitamin C reduced the duration of colds by up to 14%.64 In athletes and soldiers, daily vitamin C intake reduced the incidence of colds by 50%. A recent study found mice that were deficient in vitamin C experienced increased lung tissue damage following infection with the influenza virus. Vitamin C-deficient mice also demonstrated increased expression of pro-inflammatory cytokines. These findings suggest that vitamin C is required for an effective immune response to infection with the influenza virus.65
  • Cancer. Vitamin C may offer essential aid in fighting cancer. Higher intakes of vitamin C are associated with a decreased incidence of cancers of the mouth, throat, esophagus, stomach, colon, and lung.64 In 2005, research by the National Institutes of Health found that vitamin C administered intravenously helped kill several strains of cancer cells. This led scientists to note that intravenous vitamin C may be an important tool in fighting cancer, which supports similar findings by Linus Pauling.66 Furthermore, a recent clinical trial documented the safety of high-dose vitamin C in advanced cancer patients.67 Several recent studies indicate that the combination of lysine and proline with vitamin C more effectively inhibits cancer cells than vitamin C alone.68-79
  • Cardiovascular Disease and Stroke. Studies indicate that low or deficient intake of vitamin C is associated with an increased risk of cardiovascular disease. Similarly, the risk of death from cardiovacular diseases was found to be 25-42% lower in adults who consumed plentiful amounts of vitamin C through diet and supplements compared to adults who were deficient in vitamin C. Some research suggests that vitamin C supplements are more protective than dietary vitamin C in protecting against heart disease. Higher serum levels of vitamin C have been found to diminish the risk of suffering a stroke by up to 29%. Daily supplementation with vitamin C reduces high blood pressure, a contributor to cardiovascular and stroke risk.64

Ascovertin may also protect against some of the damaging consequences of heart attack. Studies in rats showed that Ascovertin inhibits the blood clotting and brain damage that can occur following a heart attack.21,22

The tissues of the eye may benefit from Ascovertin as well. Studies in rats found that Ascovertin inhibits damage to the eye’s retina induced by high-intensity light.23

DIHYDROQUERCETIN SUPPORTS NERVOUS SYSTEM HEALTH

The brain and nervous system are particularly sensitive to the damaging effects of free radicals. As we age, free-radical damage can accumulate in the brain, leading to cognitive decline and other illnesses such as dementia and Alzheimer’s. Maintaining optimal mental function is one of the leading goals of aging baby boomers. Fortunately, dihydroquercetin offers essential protection to critical brain and nerve cells.

To examine methods to protect the brain against injury, scientists used an animal model of stroke. Dihydroquercetin inhibited the expression of enzymes that lead to inflammation. Additionally, dihydroquercetin helped prevent inflammatory white blood cells from attacking and adhering to vulnerable areas of the brain. These actions help provide essential neuroprotection against the free-radical-induced oxidative damage that often occurs when the brain does not receive enough blood and oxygen.27,28,40

In addition to the cognitive decline that often accompanies aging, critical functions such perception, thinking, language, and consciousness can be adversely affected. Protecting the areas of the brain that oversee these functions is another important benefit of dihydroquercetin. In one study, researchers found dihydroquercetin prevented free radicals from causing oxidative damage to crucial nerve cells that oversee these functions.41

By protecting the cells of the brain and central nervous system, dihydroquercetin may help avert some of the most devastating changes associated with aging.

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